Amy Schumer Shows off Weight Loss (And Abs!): ‘No Filter, No Filler'

Comedian and actress Amy Schumer is ready to talk about weight loss. In a recent social media post, the 44-year-old Trainwreck star showed off her flat stomach, captioning the selfie “no filter, no filler.” This comes after the actress shared a separate photo on Instagram earlier this month proudly showing off her slimmer figure and “legs for days”, prompting praise from fans.

While Schumer is celebrating her success today, her journey hasn’t been easy. She openly shared her experience with liposuction in the past and that Ozempic never really worked for her (it actually made her quite sick). We’re taking a look at her journey—from weight-loss drugs to hormone therapy—including what worked, what didn’t and why.

Amy Schumer credits her weight loss to Mounjaro

While Schumer hasn’t share exactly how much she’s lost, she credits her recent weight loss to the GLP-1 drug Mounjaro. She says the drug, which is used to treat type 2 diabetes, has worked out “great” for her. The actress also revealed that she used telehealth company Midi Health (which she later invested in) to help manage her perimenopause symptoms.

“They put me on estrogen and progesterone because I realized I was in perimenopause,” she said. “My symptoms of being in perimenopause have disappeared. My hair is fuller, my skin is better, I have more energy,” Schumer shared on Instagram in March of this year. “I’m having a really good experience [on Mounjaro], so I wanted to keep it real with you about that.”

Why Amy Schumer quit Ozempic

Earlier this year, Schumer shared that she was on a weight-loss journey that ended with her losing 30 pounds at the time. To get there, she tried the popular GLP-1 medication Ozempic—but quickly regretted it.

“I lost 30 pounds so quick. I looked great, but I couldn’t lift my head off the pillow. So what’s the point?” Schumer said on The Howard Stern Show in January of this year. “I was bedridden. I was like, vomiting—and then you have no energy.”

“I’m in bed and my son’s like, ‘Can you play tag?’” she continued of her son, Gene. “And I’m like, ‘I can’t.’ I was shriveling.”

As for why she decided to open up about her journey, in a 2023 episode of Watch What Happens Live with Andy Cohen, Schumer said, “Everyone has been lying saying, ‘Oh smaller portions.’ Like shut the f–k up. You are on Ozempic or one of those things or you got work done. Just stop. Be real with the people. When I got lipo, I said I got lipo.”

Why Ozempic makes some people sick

One of the reasons Schumer believes she couldn’t tolerate Ozempic was because she has a gene (GDF15) that made her severely nauseous and sick during her pregnancy.

“The GDF15 protein that Schumer mentioned is produced by different cells in the body. [It] plays a role in nausea and vomiting during pregnancy and other conditions,” explains Eleanor Yusupov, DO, assistant professor at NYIT College Of Osteopathic Medicine.

While Schumer couldn’t stay on Ozempic, there are ways to feel better while on GLP-1s. “Taking the injection on a full stomach, staying hydrated and eating smaller, more frequent meals can help manage nausea,” notes Jennifer Habashy, NMD, MS, assistant medical director at Claya.

When to see a doctor about GLP-1 side effects

If you are like Schumer and are having consistent side effects from either Ozempic or another GLP-1, the best thing you can do is share your symptoms with your doctor.

Dr. Yusupov also warns that “If symptoms persist despite dietary and lifestyle modifications or become severe, medication needs to be stopped, meaning that your medical provider might either take you off the drug completely or try and find a different one that works for you and your lifestyle,” explains Dr. Yusupov.

“GLP-1 medications are highly effective. However, when they are stopped, people will have the best chance to keep the weight off if they have built healthy habits,” says Dr. Yusupov. “Making lifestyle changes is crucial, whether or not people take weight loss medications.”

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This story was originally published October 24, 2025 at 1:00 PM.