Christina Applegate's Former Co-Star Shares Rare Update as She Battles MS

Christina Applegate has kept her sense of humor amid her multiple sclerosis journey.

Following the 54-year-old actress' recent reported hospitalization, her former Married… With Children co-star, David Faustino, said his on-screen sister is just as funny as always, despite her 2021 MS diagnosis.

"I admire her being strong in the face of this, even though it's been a real blow," Faustino, 52, told Us Weekly in an interview published on Thursday, June 11. "It's been very hard for her, but she does keep her humor."

Faustino praised Applegate's "dry, sarcastic sense of humor" that she's had "since the moment I met her," noting that "nothing has changed" when it comes to her demeanor now. "She gets through this with some humor, and that's kind of her way that she moves through it," he said.

Faustino said that as his TV sister has struggled with her health, he's been sure to support her "as a person on her team that gives her as much love as I can."

"I do a lot of visits with her. A lot of texting, a lot of checking in. A lot of funny just crap that we talk about. And that's all I can do, right? Give her my love," Faustino continued. "We do have deep convos when we sit. But we also keep the laughter [going] as well."

Applegate was diagnosed with multiple sclerosis in June 2021 while filming the final season of Netflix's Dead to Me, but had been suffering from symptoms for years before receiving an official diagnosis.

Following reports in April that she had been hospitalized, the You With the Sad Eyes author took to Instagram with a message of appreciation for those who had sent their love.

"Thank you for the outpouring of love and well wishes," she wrote on Instagram at the time. "Health issues are a constant for me, but I'm a strong chick and I'm getting stronger and better every day. I'm taking a moment to focus on my health, but I'll be back with more to say soon enough."

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This story was originally published June 12, 2026 at 6:09 AM.