Rams to hand 49ers first loss

The Los Angeles Times' NFL writer, Sam Farmer, examines this week's matchups. Lines according to (O/U = over/under). Last week's record 8-7 (.533); season 44-33-1 (.571). Using point spreads with the scores Farmer predicted, the record against the spread last week would have been 7-8 (.467); season 38-39-1 (.494). Buffalo, Chicago, Indianapolis and Oakland have the week off. Times are Eastern.

CAR (3-2) at TB (2-3)

Sunday, 1 p.m.

Buccaneers 28, Panthers 23

TV: NFL Network.

Line: Panthers by 21/2. O/U: 471/2.

Everything with the Panthers runs through Christian McCaffrey, but no one seems to be able to run through this Buccaneers defense. Tampa Bay does enough to protect Jameis Winston.

CIN (0-5) at BAL (3-2)

Sunday, 1 p.m.

Ravens 24, Bengals 17

TV: None. DirecTV: 705.

Line: Ravens by 11. O/U: 48.

No wonder the Bengals are winless. They can't stop the pass or the run. Baltimore QB Lamar Jackson will wear down when he's running at this rate, but he can do this against Cincinnati.

NO (4-1) at JAC (2-3)

Sunday, 1 p.m.

Saints 27, Jaguars 20

TV: None. DirecTV: 706.

Line: Jaguars by 1. O/U: 431/2.

The Jaguars crumbled under weight of Carolina's run game. That's good news for Alvin Kamara. Teddy Bridgewater showed last week that he's more than just a game manager.

HOU (3-2) at KC (4-1)

Sunday, 1 p.m.

Chiefs 34, Texans 27

TV: CBS. DirecTV: 707.

Line: Chiefs by 4. O/U: 551/2.

The Chiefs are going to try to keep the ball in front of them, and make Deshaun Watson nickel and dime them instead of going over the top. Kansas City's offense is next level no matter who's in.

SEA (4-1) at CLE (2-3)

Sunday, 1 p.m.

Seahawks 27, Browns 17

TV: None. DirecTV: 708.

Line: Seahawks by 2. O/U: 46.

The Browns were embarrassed against the run last week, and now face a Pete Carroll-coached team that loves to grind it out on the ground. And when the Seahawks don't run, there's Russell Wilson.

WAS (0-5) at MIA (0-4)

Sunday, 1 p.m.

Redskins 24, Dolphins 20

TV: None. DirecTV: 709.

Line: Redskins by 3. O/U: 41.

Two horrendous teams. Give the edge to Washington because of the fleeting surge that often follows a coaching change ... and the fact the Redskins are playing the historically bad Dolphins.

PHI (3-2) at MIN (3-2)

Sunday, 1 p.m.

Vikings 23, Eagles 21

TV: None. DirecTV: 710.

Line: Vikings by 3. O/U: 44.

Great matchup. This is the biggest test yet for Dalvin Cook and Minnesota's excellent ground game. Here's betting he does just enough to free up opportunities for Kirk Cousins at home.

ATL (1-4) at ARI (1-3-1)

Sunday, 4 p.m.

Falcons 27, Cardinals 24

TV: None. DirecTV: 711.

Line: Falcons by 2. O/U: 511/2.

The Cardinals are riding high-ish after their first victory, but they, like the Falcons, are still a one-win team. Give the edge to the experienced Matt Ryan, going against a vulnerable defense.

SF (4-0) at LAR (3-2)

Sunday, 4 p.m.

Rams 27, 49ers 23

TV: Fox. DirecTV: 712.

Line: Rams by 3. O/U: 501/2.

The Rams have had extra time to think about their back-to-back losses. They lost at Seattle but played their most complete game. They do enough at home to slow San Francisco's impressive roll.

TEN (2-3) at DEN (1-4)

Sunday, 4:15 p.m.

Broncos 23, Titans 18

TV: None. DirecTV: 713.

Line: Broncos by 2. O/U: 401/2.

Tennessee's defense is hard on quarterbacks but has struggled against the run. That opens the door for Denver's one-two punch of Phillip Lindsay and Royce Freeman. Denver does enough on defense.

DAL (3-2) at NYJ (0-4)

Sunday, 4:15 p.m.

Cowboys 31, Jets 23

TV: CBS. DirecTV: 714.

Line: Cowboys by 7. O/U: 441/2.

Dak Prescott has been a missing person the last two games, but playing the Jets is like a successful trip to the lost & found. The Cowboys get back on track, for a week at least, with a win.

PIT (1-4) at LAC (2-3)

Sunday, 8:15 p.m.

Chargers 31, Steelers 17


Line: Chargers by 61/2. O/U: 41.

Maybe Devlin Hodges will surprise everyone if Mason Rudolph (concussion) can't play , but that's a big ask of an undrafted rookie quarterback who started the season on the practice squad.

DET (2-1-1) at GB (4-1)

Monday, 8:15 p.m.

Packers 27, Lions 24


Line: Packers by 4. O/U: 47.

Matchup is all about Aaron, but it's not just Aaron Rodgers. The Packers have found balance with Aaron Jones, and that's going to present problems for the Lions, giving them too much to handle.