Drivers heading north on the Highway 395 blue bridge between 8 p.m. Saturday and 2 a.m. Sunday will be directed into the left lane near the crest of the bridge.
Department of Transportation maintenance crews will close the right lane for guardrail repair.
The closure will extend just past the Lewis Street overpass in Pasco.
DOT chose the nighttime work hours to minimize traffic disruptions.
Southbound Highway 395 traffic will not be affected.