Sounders FC will begin its quest for a fourth-straight U.S. Open Cup title on May 29.
The Sounders and the 15 other MLS teams based in the United States will join the tournament in the third round, and possible pairings were released by U.S. Soccer on Wednesday.
Seattle will face the winner of the Tuesday match between the Atlanta Silverbacks of the North American Soccer League and the Georgia Revolution of the National Premier Soccer League.
If Georgia wins, it would travel to meet the Sounders at Starfire Sports Stadium in Tukwila at 7 p.m. If Atlanta wins, the Sounders would travel to play the Silverbacks in Atlanta at 4:30 p.m.
In a format change, sites through the first four rounds are determined by random selection.