Snow was drifting across Highway 241 north of Sunnyside faster than road crews could clear it on Wednesday.
The highway, sometimes called the Hanford road, was closed at about 5:30 a.m. because drifting snow was causing multiple spin outs of cars and semis that left the road blocked.
It was expected to remain closed from milepost 13 to 25 at least until Thursday morning, according to the Washington State Department of Transportation.
At 10 a.m. Wednesday two trucks remained stuck on the roadway, according to the transportation department. They had been cleared by afternoon, but state crews continued to work on clearing drifting snow about five to seven miles south of the intersection with Highway 24.