A 31-year-old Hermiston woman was driving west in the eastbound lanes of Interstate 82 near Hermiston when she crashed nearly head-on into another car, killing the 66-year-old driver, said the Oregon State Patrol.
Alcohol may have been the cause of the crash, police said.
The crash happened at 1:30 a.m. Friday.
Alicia G. Breckheimer of Hermiston was driving a 2005 Cadillac CTS four-door and Robert Henry Baker of Ione, Ore., was driving a 2006 Chrysler 300 four-door, police said. He was pronounced dead at the scene.
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After the collision, the Cadillac came to rest in the center median and the Chrysler came to rest on the eastbound shoulder.
Breckheimer was extricated by firefighters and initially taken by Hermiston Ambulance to Good Shepherd Medical Center in Hermiston and later flown to Legacy Emanuel Medical Center in Portland.
Both drivers were wearing seat belts.
Oregon troopers from Hermiston and Pendleton are investigating. The eastbound lanes were closed more than an hour before one lane was open for traffic as OSP collision reconstructionists continued the scene investigation.
OSP was assisted at the scene by Morrow County Sheriff's Office, Umatilla Police Department, Hermiston fire and ambulance, and the Oregon Department of Transportation.
The most recent available crash statistics from the National Highway Traffic Safety Administration indicates wrong-way drivers are involved in 1.5 percent of all fatal crashes nationally, police said.