Here is the schedule for Week 2 in the 2011 Mid-Columbia high school football season:
Thursday, Sept. 8
| Nonleague | ||
| Enterprise, Ore | 14 | |
| Dayton | 26 | F |
| Tri-Cities Prep | 46 | |
| Pendleton JV | 6 | F |
Friday, Sept. 9
| CWAC | ||
| Ellensburg | 8 | |
| East Valley | 7 | F |
| Prosser | 36 | |
| Ephrata | 17 | F |
| Quincy | 8 | |
| Othello | 48 | F |
| Selah | 46 | |
| Wapato | 21 | F |
| Toppenish | 15 | |
| Grandview | 7 | F |
| Nonleague | ||
| Moses Lake | 21 | |
| Kamiakin (Lampson Stadium) | 37 | F |
| Kennewick | 34 | |
| Hermiston | 0 | F |
| Hanford | 21 | |
| Richland | 35 | F |
| Pasco | 14 | |
| Chiawana (Edgar Brown Stadium) | 22 | F |
| Eastmont | 19 | |
| Wenatchee | 40 | F |
| Walla Walla | 22 | |
| Southridge (Lampson Stadium) | 42 | F |
| Almira-Coulee-Hartline | 46 | |
| Liberty Christian (at Hanford HS) | 44 | F |
| Colton | 38 | |
| Salmon River, Idaho | 30 | F |
| Columbia-Burbank | 30 | |
| LaSalle | 20 | F |
| Condon | 8 | |
| Touchet | 50 | F |
| Connell | 35 | |
| Chelan | 0 | F |
| DeSales | 13 | |
| Colfax | 20 | F |
| Echo | 14 | |
| Cove | 51 | F |
| Eisenhower | 44 | |
| West Valley | 13 | F |
| Granger | 52 | |
| Mabton | 7 | F |
| Grangeville, Idaho | 51 | |
| Asotin | 6 | F |
| LaCrosse-Washtucna | 42 | |
| Kootenai, Idaho | 14 | F |
| Liberty | 0 | |
| Tekoa-Oakesdale-Rosalia | 84 | F |
| Lyle | 14 | |
| Sunnyside Christian (Sunnyside HS) | 0 | F |
| Riverside | 29 | |
| Stanfield | 58 | F |
| River View | 34 | |
| Goldendale (moved to Art Fiker, Prosser) | 26 | F |
| Royal | 41 | |
| Omak | 0 | F |
| Selkirk | 0 | |
| Garfield-Palouse | 44 | F |
| Sunnyside | 18 | |
| Davis (Zaepfel Stadium) | 26 | F |
| Umatilla | 21 | |
| Elgin | 0 | F |
| Waitsburg-Prescott | 60 | |
| Pilot Rock | 14 | F |
| Warden | 21 | |
| Lind-Ritzville | 27 | F |
| Zillah | 14 | |
| Kiona-Benton | 12 | F |
